We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prospective Cohort Study of COVID-19 Vaccination, SARS-CoV-2 Infection, and Fertility.
- Authors
Wesselink, Amelia K; Hatch, Elizabeth E; Rothman, Kenneth J; Wang, Tanran R; Willis, Mary D; Yland, Jennifer; Crowe, Holly M; Geller, Ruth J; Willis, Sydney K; Perkins, Rebecca B; Regan, Annette K; Levinson, Jessica; Mikkelsen, Ellen M; Wise, Lauren A
- Abstract
Some reproductive-aged individuals remain unvaccinated against coronavirus disease 2019 (COVID-19) because of concerns about potential adverse effects on fertility. Using data from an internet-based preconception cohort study, we examined the associations of COVID-19 vaccination and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with fertility among couples trying to conceive spontaneously. We enrolled 2,126 self-identified female participants aged 21–45 year residing in the United States or Canada during December 2020–September 2021 and followed them through November 2021. Participants completed questionnaires every 8 weeks on sociodemographics, lifestyle, medical factors, and partner information. We fit proportional probabilities regression models to estimate associations between self-reported COVID-19 vaccination and SARS-CoV-2 infection in both partners with fecundability (i.e. the per-cycle probability of conception), adjusting for potential confounders. COVID-19 vaccination was not appreciably associated with fecundability in either partner (female fecundability ratio (FR) = 1.08, 95% confidence interval (CI): 0.95, 1.23; male FR = 0.95, 95% CI: 0.83, 1.10). Female SARS-CoV-2 infection was not strongly associated with fecundability (FR = 1.07, 95% CI: 0.87, 1.31). Male infection was associated with a transient reduction in fecundability (for infection within 60 days, FR = 0.82, 95% CI: 0.47, 1.45; for infection after 60 days, FR = 1.16, 95% CI: 0.92, 1.47). These findings indicate that male SARS-CoV-2 infection may be associated with a short-term decline in fertility and that COVID-19 vaccination does not impair fertility in either partner.
- Subjects
UNITED States; CANADA; RISK factors in infertility; COVID-19; CONFIDENCE intervals; COVID-19 vaccines; SELF-evaluation; REGRESSION analysis; RISK assessment; FERTILITY; QUESTIONNAIRES; DESCRIPTIVE statistics; ATTITUDES toward pregnancy; STATISTICAL models; SEXUAL partners; LONGITUDINAL method
- Publication
American Journal of Epidemiology, 2022, Vol 191, Issue 8, p1383
- ISSN
0002-9262
- Publication type
Article
- DOI
10.1093/aje/kwac011