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- Title
Chronic metabolic acidosis in azotemic rats on a high-phosphate diet halts the progression of renal disease.
- Authors
Jara, Aquiles; Felsenfeld, Arnold J.; Bover, Jordi; Kleeman, Charles R.
- Abstract
Chronic metabolic acidosis in azotemic rats on a high-phosphate diet halts the progression of renal disease. Background. Hyperphosphatemia and metabolic acidosis are general features of advanced chronic renal failure (RF), and each may affect mineral metabolism. The goal of the present study was to evaluate the effect of chronic metabolic acidosis on the development of hyperparathyroidism and bone disease in normal and azotemic rats on a high-phosphate diet. Our assumption that the two groups of azotemic rats (acid-loaded vs. non–acid-loaded) would have the same degree of renal failure at the end of the study proved to be incorrect. Methods. Four groups of rats receiving a high-phosphate (1.2%), normal-calcium (0.6%) diet for 30 days were studied: (1) normal (N); (2) normal + acid (N + Ac) in which 1.5% ammonium chloride (NH4Cl) was added to the drinking water to induce acidosis; (3) RF, 5/6 nephrectomized rats; and (4) RF + acid (RF + Ac) in which 0.75% NH4Cl was added to the drinking water of 5/6 nephrectomized rats to induce acidosis. Results. At sacrifice, the arterial pH and serum bicarbonate were lowest in the RF + Ac group and were intermediate in the N + Ac group. Serum creatinine (0.76 ± 0.08 vs. 1.15 ± 0.08 mg/dL), blood urea nitrogen (52 ± 8 vs. 86 ± 13 mg/dL), parathyroid hormone (PTH; 180 ± 50 vs. 484 ± 51 pg/mL), and serum phosphate (7.46 ± 0.60 vs. 12.87 ± 1.4 mg/dL) values were less (P < 0.05), and serum calcium (9.00 ± 0.28 vs. 7.75 ± 0.28 mg/dL) values were greater (P < 0.05) in the RF + Ac group than in the RF group. The fractional excretion of phosphate (FEP) was greater (P < 0.05) in the two azotemic groups than in the two nonazotemic groups. In the azotemic groups, the FEP was similar even though PTH and serum phosphate values were less in the RF + Ac than in the RF group. NH4Cl-induced acidosis produced hypercalciuria in the N +...
- Subjects
ACIDOSIS; HYPERPARATHYROIDISM; OSTEITIS fibrosa
- Publication
Kidney International, 2000, Vol 58, Issue 3, p1023
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1046/j.1523-1755.2000.00260.x