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- Title
Antidiabetic and Antihyperlipidemic Effects of Thespesia populnea Fruit Pulp Extracts on Alloxan-induced Diabetic Rats.
- Authors
BELHEKAR, S. N.; CHAUDHARI, P. D.; SARYAWANSHI, J. S.; MALI, K. K.; PANDHARE, R. B.
- Abstract
Present study was carried to find out the antihyperglycemic and antihyperlipidemic activity of ethanol and aqueous extract of Thespesia populnea fruit pulp on alloxan-induced diabetic rats. Diabetes was induced in rats by administration of alloxan (150 mg/kg, i.p.). After the successful induction of experimental diabetes, the rats were divided into five groups each comprising a minimum of six rats. Phytochemical analysis and acute toxicity study of extracts was also done. The effects of extracts and metformin on fasting blood glucose and plasma lipid were examined for 28 days. Statistical analysis was carried out by using analysis of variance followed by Dunnet's multiple comparison test and paired t-test were done as the test of significance using GraphPad Prism. P≤0.05 was considered as the minimal level of statistical significance. Therapeutic dose of extract was found to be 200 mg/kg on the basis of acute toxicity study. Aqueous and alcoholic extract showed a significant reduction in blood glucose levels as well as a lipid profile of diabetic rats at the end of 28th day of treatment. However, in groups treated with plant extract the reduction in the blood glucose and improvement in lipid profile was slightly less than that achieved with the standard group (metformin). From this study, it can be concluded that ethanol and aqueous extract of Thespesia populnea exhibited significant antihyperglycemic and antihyperlipidemic effects on alloxan-induced diabetic rats.
- Subjects
HYPOGLYCEMIC agents; HYPERLIPIDEMIA treatment; THESPESIA populnea; ALLOXAN diabetes; PHYTOCHEMICALS; METFORMIN; LABORATORY rats
- Publication
Indian Journal of Pharmaceutical Sciences, 2013, Vol 75, Issue 2, p217
- ISSN
0250-474X
- Publication type
Article