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- Title
Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6.
- Authors
Weller, Melodie L.; Amornphimoltham, Panomwat; Schmidt, Michael; Wilson, Paul A.; Gutkind, J. Silvio; Chiorini, John A.
- Abstract
A key step in gene therapy is the efficient transfer of genes in a cell type– and tissue-specific manner. To better understand the mechanism of adeno-associated virus serotype 6 (AAV6) transduction, we used comparative gene analysis (CGA) combined with pathway visualization software to identify a positive correlation between AAV6 transduction and epidermal growth factor receptor (EGFR) expression. Subsequent experiments suggested that EGFR is necessary for vector internalization and probably functions as a co-receptor for AAV6.
- Subjects
GENE therapy; GROWTH factors; SEROTYPES; THERAPEUTICS; VISUAL perception
- Publication
Nature Medicine, 2010, Vol 16, Issue 6, p662
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm.2145