We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A genome-wide association study identifies susceptibility loci for Wilms tumor.
- Authors
Turnbull, Clare; Perdeaux, Elizabeth R; Pernet, David; Naranjo, Arlene; Renwick, Anthony; Seal, Sheila; Munoz-Xicola, Rosa Maria; Hanks, Sandra; Slade, Ingrid; Zachariou, Anna; Warren-Perry, Margaret; Ruark, Elise; Gerrard, Mary; Hale, Juliet; Hewitt, Martin; Kohler, Janice; Lane, Sheila; Levitt, Gill; Madi, Mabrook; Morland, Bruce
- Abstract
Wilms tumor is the most common renal malignancy of childhood. To identify common variants that confer susceptibility to Wilms tumor, we conducted a genome-wide association study in 757 individuals with Wilms tumor (cases) and 1,879 controls. We evaluated ten SNPs in regions significantly associated at P < 5 × 10?5 in two independent replication series from the UK (769 cases and 2,814 controls) and the United States (719 cases and 1,037 controls). We identified clear significant associations at 2p24 (rs3755132, P = 1.03 × 10?14; rs807624, P = 1.32 × 10?14) and 11q14 (rs790356, P = 4.25 × 10?15). Both regions contain genes that are plausibly related to Wilms tumorigenesis. We also identified candidate association signals at 5q14, 22q12 and Xp22.
- Subjects
UNITED States; NEPHROBLASTOMA; KIDNEY diseases; TRANSFORMING growth factors; TUMOR growth; MOLECULAR carcinogenesis; GENETICS
- Publication
Nature Genetics, 2012, Vol 44, Issue 6, p681
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.2251