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- Title
Features of airway remodeling in different types of Chinese chronic rhinosinusitis are associated with inflammation patterns.
- Authors
Shi, L‐L.; Xiong, P.; Zhang, L.; Cao, P‐P.; Liao, B.; Lu, X.; Cui, Y‐H.; Liu, Z.
- Abstract
Background The remodeling patterns in different types of chronic rhinosinusitis ( CRS) have rarely been compared, particularly the difference between eosinophilic and noneosinophilic CRS with nasal polyps ( CRSw NP). Moreover, whether there is a link between remodeling and inflammation remains controversial. Objective To directly compare the remodeling features of different CRS and to explore their relationship with inflammation in Chinese patients. Methods Histologic characteristics of surgical samples were analyzed in 33 controls, 72 eosinophilic and 76 noneosinophilic CRSw NP, and 72 CRS without nasal polyps ( CRSs NP) patients. Tissue samples from 38 controls, 26 eosinophilic and 26 noneosinophilic CRSw NP, and 32 CRSs NP patients were measured for mRNA and/or protein expression of profibrotic growth factors, metalloproteinases ( MMPs), tissue inhibitor of metalloproteinases ( TIMPs), hypoxia-inducible factor ( HIF)-1α, interleukin ( IL)-8, eosinophil cationic protein ( ECP), and myeloperoxidase ( MPO). Results The amount of collagen decreased, whereas the edema scores increased, from CRSs NP to noneosinophilic CRSw NP and to eosinophilic CRSw NP. Transforming growth factor ( TGF)-β2 protein levels were enhanced in CRSs NP compared with CRSw NP. TIMP-4 protein levels decreased in eosinophilic CRSw NP compared with noneosinophilic CRSw NP and CRSs NP. The number of neutrophils decreased from CRSs NP to noneosinophilic CRSw NP and to eosinophilic CRSw NP. ECP levels were only up-regulated in eosinophilic CRSw NP. ECP levels and neutrophil number correlated positively with the severity of edema and fibrosis, respectively. Neutrophils were the major sources of TGF-β2 in CRSs NP and noneosinophilic CRSw NP. Conclusion Distinct remodeling patterns are revealed for different types of CRS, particularly for eosinophilic and noneosinophilic CRSw NP. Tissue remodeling associates with inflammation in CRS.
- Subjects
AIRWAY (Anatomy); CHINESE people; SINUSITIS; INFLAMMATION; MYELOPEROXIDASE; INTERLEUKINS; TISSUE inhibitors of metalloproteinases; DISEASES
- Publication
Allergy, 2013, Vol 68, Issue 1, p101
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.12064