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- Title
Radiopharmaceuticals for Skeletal Muscle PET Imaging.
- Authors
Park, Joo Yeon; Park, Sun Mi; Lee, Tae Sup; Kang, Seo Young; Kim, Ji-Young; Yoon, Hai-Jeon; Kim, Bom Sahn; Moon, Byung Seok
- Abstract
The skeletal muscles account for approximately 40% of the body weight and are crucial in movement, nutrient absorption, and energy metabolism. Muscle loss and decline in function cause a decrease in the quality of life of patients and the elderly, leading to complications that require early diagnosis. Positron emission tomography/computed tomography (PET/CT) offers non-invasive, high-resolution visualization of tissues. It has emerged as a promising alternative to invasive diagnostic methods and is attracting attention as a tool for assessing muscle function and imaging muscle diseases. Effective imaging of muscle function and pathology relies on appropriate radiopharmaceuticals that target key aspects of muscle metabolism, such as glucose uptake, adenosine triphosphate (ATP) production, and the oxidation of fat and carbohydrates. In this review, we describe how [18F]fluoro-2-deoxy-D-glucose ([18F]FDG), [18F]fluorocholine ([18F]FCH), [11C]acetate, and [15O]water ([15O]H2O) are suitable radiopharmaceuticals for diagnostic imaging of skeletal muscles.
- Subjects
POSITRON emission tomography; RADIOPHARMACEUTICALS; COMPUTED tomography; ADENOSINE triphosphate; MUSCLE metabolism; SKELETAL muscle
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 9, p4860
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25094860