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- Title
Congenital anomalies and the severity of impairments for cerebral palsy.
- Authors
Jystad, Kjersti P; Strand, Kristin M; Bjellmo, Solveig; Lydersen, Stian; Klungsöyr, KARI; Stoknes, Magne; Skranes, Jon; Andersen, Guro L; Vik, Torstein
- Abstract
<bold>Aim: </bold>To study the prevalence of congenital anomalies among children with cerebral palsy (CP) born at term or late preterm, and if CP subtypes and clinical manifestations differ between children with and without congenital anomalies.<bold>Method: </bold>This was a cross-sectional study using data from the Cerebral Palsy Register of Norway and the Medical Birth Registry of Norway. All children with congenital CP born at and later than 34 weeks' gestation in Norway from 1999 to 2009 were included. Anomalies were classified according to the European Surveillance of Congenital Anomalies classification guidelines. Groups were compared using Fisher's exact test, Kruskal-Wallis test, and the Mann-Whitney U test.<bold>Results: </bold>Among 685 children with CP, 169 (25%) had a congenital anomaly; 125 within the central nervous system. Spastic bilateral CP was more prevalent in children with anomalies (42%) than in children without (34%; p=0.011). Children with anomalies less frequently had low Apgar scores (p<0.001), but more often had severe limitations in gross- and fine-motor function, speech impairments, epilepsy, severe vision, and hearing impairments than children without anomalies (p<0.03).<bold>Interpretation: </bold>Although children with CP and anomalies had low Apgar scores less frequently, they had more severe limitations in motor function and more associated problems than children with CP without anomalies.<bold>What This Paper Adds: </bold>One in four children with cerebral palsy (CP) born at term or late preterm has a congenital anomaly. The added value of neuroimaging to detect central nervous system anomalies in children with CP. Children with anomalies have more severe motor impairments. More severe clinical manifestations are not explained by perinatal complications as indicated by low Apgar scores.
- Subjects
NORWAY; CONGENITAL disorders; CHILDREN with cerebral palsy; CENTRAL nervous system diseases; MOVEMENT disorders; BRAIN imaging; APGAR score; CEREBRAL dominance; CEREBRAL palsy; GESTATIONAL age; HEALTH planning; LONGITUDINAL method; NERVOUS system abnormalities; CROSS-sectional method; SEVERITY of illness index; ODDS ratio; DISEASE complications
- Publication
Developmental Medicine & Child Neurology, 2017, Vol 59, Issue 11, p1174
- ISSN
0012-1622
- Publication type
journal article
- DOI
10.1111/dmcn.13552