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- Title
Spontaneous periodic hypothermia and hyperhidrosis: a possibly novel cerebral neurotransmitter disorder.
- Authors
MASRUHA, MARCELO RODRIGUES; LIN, JAIME; ARITA, JULIANA HARUMI; NETO, EDUARDO FERREIRA DE CASTRO; SCERNI, DÉBORA AMADO; CAVALHEIRO, ESPER ABRÃO; MAZZACORATTI, MARIA DA GRAÇ NAFFAH; VILANOVA, LUIZ CELSO PEREIRA
- Abstract
Spontaneous periodic episodes of hypothermia still defy medical knowledge. In 1969, Shapiro et al. described the first two cases of spontaneous periodic hypothermia associated with agenesis of the corpus callosum. Recently, Dundar et al. reported a case of spontaneous periodic hypothermia and hyperhidrosis without corpus callosum agenesis, suggesting that the periodic episodes of hypothermia might be of epileptiform origin. Here we describe two paediatric patients with spontaneous periodic hypothermia without corpus callosum agenesis and demonstrate, to our knowledge for the first time, altered levels of neurotransmitter metabolites within the cerebrospinal fluid.
- Subjects
HYPOTHERMIA; CORPUS callosum; POTTER'S syndrome; NEUROTRANSMITTERS; METABOLITES
- Publication
Developmental Medicine & Child Neurology, 2011, Vol 53, Issue 4, p378
- ISSN
0012-1622
- Publication type
Article
- DOI
10.1111/j.1469-8749.2010.03854.x