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- Title
Prodynorphin storage and processing in axon terminals and dendrites.
- Authors
Yakovleva, Tatiana; Bazov, Igor; Cebers, Gvido; Marinova, Zoya; Hara, Yuko; Ahmed, Aisha; Vlaskovska, Mila; Johansson, Björn; Hochgeschwender, Ute; Singh, Indrapal N.; Bruce-Keller, Annadora J.; Hurd, Yasmin L.; Kaneko, Takeshi; Terenius, Lars; Ekström, Tomas J.; Hauser, Kurt F.; Pickel, Virginia M.; Bakalkin, Georgy
- Abstract
The article discusses a study which tested a model that postulates that neuropeptide precursor in neurons are processed into mature neuropeptides in the somatic trans-Golgi network and in secretory vesicles during axonal transport. Researchers characterize prodynorphin, precursor protein to the dynorphin opioid peptides. They also identify cellular distribution and subcellular sites in neurons in which this protein is stored and processed to mature peptides.
- Subjects
NEUROPEPTIDES; NERVE tissue proteins; NEURONS; PROTEIN precursors; OPIOID peptides; PEPTIDES
- Publication
FASEB Journal, 2006, Vol 20, Issue 12, p2124
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.06-6174fje