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- Title
Sodium/myo-inositol cotransporter-1 is essential for the development and function of the peripheral nerves.
- Authors
Chau, Jenny F. L.; Lee, M. K.; Law, Janice W. S.; Chung, Sookja K.; Chung, Stephen S. M.
- Abstract
Assesses the contribution of sodium/myo-inositol cotransporter-1 (SMIT-1) to the cellular level of myoinositol (MI) in different tissues using an SMIT-1 gene knockout mice. Death of SMIT-1 null mice due to respiratory failure soon after birth; Prevention of neonatal lethality of the SMIT-null mice by prenatal maternal MI supplement; Role of SMIT-1 deficiency in impairing the development of peripheral nerves.
- Subjects
INOSITOL; GENES; LABORATORY mice; PERIPHERAL nervous system; RESPIRATORY insufficiency; ALCOHOLS (Chemical class); SUGARS
- Publication
FASEB Journal, 2005, Vol 19, Issue 13, p1887
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.05-4192fje