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- Title
Efecto de una dieta de patrón mediterráneo en la respuesta metabólica secundaria a la pérdida de peso; papel del polimorfismo de un único nucleótido (rs16147) del gen del neuropéptido Y.
- Authors
Primo, David; Izaola, Olatz; José López, Juan; Gómez, Emilia; Ortolá, Ana; Delgado, Esther; Díaz, Gonzalo; Torres, Beatriz; de Luis, Daniel Antonio; Primo Martín, David; Izaola Jáuregui, Olatz; López Gómez, Juan José; Gómez Hoyos, Emilia; Ortolá Buigues, Ana; de Luis Román, Daniel A; Torres Torres, Beatriz
- Abstract
<bold>Introduction: </bold>Background and aims: intervention studies that evaluate the effect of rs16147 on metabolic response and weight change after dietary intervention are scarce. We propose to evaluate the role of the rs16147 genetic variant in the metabolic effects produced by a hypocaloric Mediterranean-pattern diet with high content of omega-9. Material and methods: a sample of 363 obese subjects was recruited. At the baseline visit the patients were randomly assigned to one of two hypocaloric diets for 12 weeks (diet M, Mediterranean pattern; diet C, standard hypocaloric). All patients, at baseline and at 12 weeks, had biochemical and anthropometric variables measured, and genotyping performed for the rs16147 variant. Results: in all subjects, and with both diets, the parameters of adiposity, blood pressure, and circulating leptin improved. In obese subjects with allele (A) insulin levels (GG vs. GA + AA) (-0.9 ± 1.1 IU/L vs. -4.4 ± 1.0 IU/L; p = 0.01) and HOMA-IR (-0.3 ± 0.1 units vs. -1.2 ± 0.3 units; p = 0.02) decreased significantly with diet M. Subjects carrying the minor allele showed a significant decrease in basal insulin levels (GG vs. GA + AA) (0.7 ± 0.3 IU/L vs. -2.2 ± 0.9 IU/L: p = 0.02) and HOMA-IR (-0.3 ± 0.2 units vs. -0.7 ± 0.1 units: p = 0.01) after diet C. This decrease in circulating insulin and HOMA-IR levels in patients with allele A was significantly higher with diet M than with diet C. Conclusions: the A allele of the rs16147 variant produces a better metabolic response in terms of insulin resistance and basal insulin secondary to weight loss with two different hypocaloric diets in obese subjects, with improvement being higher with the Mediterranean diet.
- Subjects
REDUCING diets; OBESITY; MEDITERRANEAN diet; RESEARCH; NEUROPEPTIDES; RESEARCH methodology; ARTHRITIS Impact Measurement Scales; GENETIC polymorphisms; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; RANDOMIZED controlled trials; WEIGHT loss
- Publication
Nutrición Hospitalaria, 2020, Vol 37, Issue 4, p742
- ISSN
0212-1611
- Publication type
journal article
- DOI
10.20960/nh.02941