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- Title
MicroRNA-21 protects from mesangial cell proliferation induced by diabetic nephropathy in db/db mice
- Authors
Zhang, Zheng; Peng, Huimin; Chen, Junxia; Chen, Xin; Han, Fei; Xu, Xiaoming; He, Xiaoyan; Yan, Ning
- Abstract
Abstract: Diabetic nephropathy (DN) is a major diabetic complication. But the initiating molecular events triggering DN are unknown. Recent researches have addressed the role of microRNAs in diabetes and its complications. In this study, we looked for microRNAs expression during early DN, and showed microRNA-21 (miR-21) expression was downregulated in response to early DN in vitro and in vivo. Over-expression of miR-21 inhibited proliferation of mesangial cells and decreased the 24-h urine albumin excretion rate in diabetic db/db mice. Moreover, we identified PTEN as a target of miR-21. We also found PI3K and p-Akt increased in miR-21 treated mesangial cells and db/db mice. Overall, these studies for the first time provide evidence for the potential role of miR-21 in early DN.
- Subjects
DIABETIC nephropathies; CELL proliferation -- Molecular aspects; GENE expression; GENE targeting; LABORATORY mice; NON-coding RNA
- Publication
FEBS Letters, 2009, Vol 583, Issue 12, p2009
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2009.05.021