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- Title
Case of rapidly progressing condylomatous squamous cell carcinoma of the uterine cervix associated with low‐risk human papillomavirus type 6.
- Authors
Masuda, Miho; Abiko, Kaoru; Minamiguchi, Sachiko; Murakami, Ryusuke; Baba, Tsukasa; Konishi, Ikuo
- Abstract
Abstract: Condylomatous, or warty squamous cell carcinoma (SCC) of the uterine cervix, is a rare variant of invasive SCC. Here, we describe a case of aggressive condylomatous SCC of the uterine cervix. A 43‐year‐old woman was monitored for 3 years for suspected low‐grade squamous intraepithelial lesion. A whitish papillary mass occupied the cervix, and the colposcopic diagnosis was <italic>condyloma acuminatum.</italic> A cervical biopsy revealed papillary proliferating thick squamous epithelium, which consisted of koilocytes and atypical cells with enlarged nuclei. Hysterectomy specimens showed a thick layer of atypical squamous epithelium with koilocytosis invading the stroma. Immunohistochemistry revealed negative p16 expression. Hysterectomy specimens tested positive for low‐risk human papillomavirus type 6, but negative for other high‐risk human papillomavirus types. The bilateral pelvic and para‐aortic lymph nodes were positive for metastases. In spite of adjuvant chemotherapy, the case relapsed with multiple lymph nodes and lung metastases shortly after the operation.
- Subjects
CERVICAL cancer treatment; CANCER treatment; GENITAL warts; BIOPSY; CERVICAL cancer; COLPOSCOPY; COMBINED modality therapy; GENE expression; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; LYMPH nodes; METASTASIS; PAPILLOMAVIRUSES; SQUAMOUS cell carcinoma; DISEASE relapse; CERVICAL intraepithelial neoplasia; TUMOR grading; DISEASE complications; DIAGNOSIS
- Publication
Journal of Obstetrics & Gynaecology Research, 2018, Vol 44, Issue 3, p583
- ISSN
1341-8076
- Publication type
Case Study
- DOI
10.1111/jog.13553