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- Title
Potassium Hydroxide/Dimethyl Sulfoxide Superbase-Promoted Transition Metal-Free Synthesis of 2-Substituted Benzothiophenes under Visible Light.
- Authors
Gao, Li; Chang, Bin; Qiu, Wenzhao; Wang, Lele; Fu, Xianzhi; Yuan, Rusheng
- Abstract
A potassium hydroxide/dimethyl sulfoxide (KOH/DMSO) superbase-promoted method for the synthesis of 2-substituted benzothiophenes has been developed via photoinduced intermolecular annulation of 2-halothioanisoles with terminal alkynes at ambient temperature. The present protocol uses commercially available 2-halothioanisoles as substrates and visible light as energy force, which offers a wide range of benzothiophenes regioselectively in moderate to good yields. Such a facile and effective transformation will provide an environment-friendly approach to the synthesis of benzothiophene derivatives.
- Subjects
CHEMICAL synthesis; THIOPHENES; POTASSIUM hydroxide; DIMETHYL sulfoxide; SUPERBASES (Chemistry); TRANSITION metals; VISIBLE spectra; BENZENE derivatives
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 8, p1202
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201501136