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- Title
Semi-automated radiosynthesis of F-labeled l-arginine derivative as a potential PET tracer for lung cancer imaging.
- Authors
Gao, Siyuan; Tang, Ganghua; Zhu, Shuguang; Hu, Kongzhen; Yao, Shaobo; Tang, Caihua; Yang, Chen; Wang, Youdi; Li, Jiahong; Pan, Xuediao; Guo, Jiquan; Wang, Qiyou; Gao, Ruiping; Zhang, Wei; Wang, Junye; Huang, Jinhua; Zang, Linquan
- Abstract
In this work, we designed and synthesized N-(2-[F]-flouroptopionyl)- l-arginine ([F]FPARG), which was an analogue of l-arginine for tumor positron emission tomography (PET) imaging. Semi-automated radiosynthesis of [F]FPARG was performed from the reaction of l-arginine with 4-nitropheyl-2-[F]flouropropionate ([F]NFP) by multi-step procedure on the modified PET-MF-2V-IT-1 synthesizer. The uncorrected radiochemical yield of [F]FPARG was 15 ± 3 % (n = 10) with more than 98 % radiochemical purity. The small-animal PET/CT fused imaging showed that liver and urinary bladder were the primary excretion route of this tracer.
- Subjects
LUNG cancer diagnosis; ARGININE derivatives; RADIOCHEMICAL yield; TRACERS (Chemistry); AUTOMATION; POSITRON emission tomography
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2016, Vol 309, Issue 3, p1257
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-016-4719-3