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- Title
Labeling of ursodeoxycholic acid with technetium-99m for hepatobiliary imaging.
- Authors
Sanad, M.; El-Tawoosy, M.
- Abstract
An adopted method for the preparation of high radiochemical purity Tc-ursodeoxycholic acid (UDCA) was conducted with a high radiochemical yield up to 97.5 %. The reaction proceeds well using 2 mg UDCA, 50 μg tin chloride in solution of pH 8 at room temperature for 30 min. The radiochemical yield was up to 97.5 % as pure as Tc-UDCA. Different chromatographic techniques (paper chromatography and electrophoresis) were used to evaluate the radiochemical yield and purity of the labeled product. Biodistribution studies were carried out in Albino Swiss mice at different time intervals after administration of Tc-UDCA. The uptake of Tc-UDCA in the liver gave the chance to diagnose it. The results indicate that the labeled compound cleared from the systematic circulation within 2 h after administration and majority of organs showed significant decrease in uptake of Tc-UDCA. Finally, the liver uptake was high and the results indicate the possibility of using Tc-UDCA for hepatobiliary imaging.
- Subjects
URSODEOXYCHOLIC acid; TECHNETIUM isotopes; RADIOCHEMICAL yield; LABORATORY mice; ELECTROPHORESIS
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2013, Vol 298, Issue 2, p1105
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-013-2512-0