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- Title
Intertwined relationship of dynamin-related protein 1, mitochondrial metabolism and circadian rhythm.
- Authors
Latha Laxmi, Indrani Paramasivan; Job, Anica Tholath; Manickam, Venkatraman; Tamizhselvi, Ramasamy
- Abstract
In recent years, mitochondria have gained significant interest in the field of biomedical research due to their impact on human health and ageing. As mitochondrial dynamics are strongly controlled by clock genes, misalignment of the circadian rhythm leads to adverse metabolic health effects. In this review, by exploring various aspects of research and potential links, we hope to update the current understanding of the intricate relationship between DRP1-mediated mitochondrial dynamics and changes in circadian rhythmicity leading to health issues. Thus, this review addresses the potential bidirectional relationships between DRP1-linked mitochondrial function and circadian rhythm misalignment, their impact on different metabolic pathways, and the potential therapeutics for metabolic and systemic disorders.
- Subjects
CIRCADIAN rhythms; MITOCHONDRIAL dynamics; CLOCK genes; CHRONOBIOLOGY disorders; MITOCHONDRIA; MOLECULAR clock
- Publication
Molecular Biology Reports, 2024, Vol 51, Issue 1, p1
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-024-09430-8