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- Title
MiR-196: emerging of a new potential therapeutic target and biomarker in colorectal cancer.
- Authors
Pourdavoud, Peyman; Pakzad, Bahram; Mosallaei, Meysam; Saadatian, Zahra; Esmaeilzadeh, Emran; Alimolaie, Asma; Shaygannejad, Alireza
- Abstract
Deregulation of microRNAs, as key elements in colorectal cancer (CRC) pathogenesis, is correlated with various stages of this cancer. miR-196 is involved in the initiation and progression of a verity of malignances, especially CRC. miR-196 in CRC cells could target different types of genes with oncogenic and/or tumor suppressor function such as HOX genes, GATA6, SOCS1, SOCS3, ANXA1, DFFA, PDCD4, ZG16 and ING5. Therefore, these genes could be up or down-regulated in cells and subsequently change the capacity of CRC cells in terms of tumor development, progression and, response to therapy. Comprehension of miR-196-associated aberrations underlying the CRC pathogenesis might introduce promising targets for therapy. Additionally, it seems that miR-196 expression profiling, especially circulatory exosomal miR-196, might be useful for diagnosis and prognosis determination of the CRC patients. In this review, at first, we summarize the roles of miR-196 in different types of cancers. After that, a detailed discussion about this miRNA and also their targets in CRC pathogenesis, progression, and response to treatment are represented. Moreover, we highlight the potential utilization of miR-196 and its targets as therapeutic targets and novel biomarkers in early detection and prediction of prognosis in CRC patients.
- Subjects
COLORECTAL cancer; BIOMARKERS; HOMEOBOX genes; ONCOGENES; TUMOR classification; MICRORNA
- Publication
Molecular Biology Reports, 2020, Vol 47, Issue 12, p9913
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-020-05949-8