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- Title
The Human Lung Cell Line A549 Does Not Develop Adaptive Protection Against the DNA-Damaging Action of Formaldehyde.
- Authors
Speit, Günter; Neuss, Simone; Schmid, Oliver
- Abstract
The article presents a study that examines the role of Formaldehyde (FA) on DNA-protein crosslink (DPX) inductions and removal in human lung cell line A549. The study measures DPX inductions of FA-treated A549 cells using alkaline comet assay. Result shows DPX induction similarities between single and low repetitive FA treatments, which enhances in higher FA concentration pretreatments. It concludes that A549 cells do not develop an adaptive protection against FA genotoxic process.
- Subjects
DNA-protein interactions; FORMALDEHYDE; DNA damage; EFFECT of chemicals on human cell culture; MICROBIOLOGICAL assay; GENETIC toxicology
- Publication
Environmental & Molecular Mutagenesis, 2010, Vol 51, Issue 2, p130
- ISSN
0893-6692
- Publication type
Article
- DOI
10.1002/em.20524