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- Title
Chromosomal Aberrations in Railroad Transit Workers: Effect of Genetic Polymorphisms.
- Authors
Catalán, Julia; Heilimo, Iiris; Falck, Ghita C.-M.; Järventaus, Hilkka; Rosentröm, Päivi; Nykyri, Erkki; Kallas-Tarpila, Tarja; Pitkämäki, Leena; Hirvonen, Ari; Norppa, Hannu
- Abstract
The article presents a study which investigates the effect of genotoxic components exposure to chromosomal aberrations (CA) in peripheral lymphocytes of railroad transit workers. Forty-eight railroad workers and 39 referents, which are male smokers and nonsmokers, were surveyed about their medical history and lifestyle. Peripheral blood samples were collected and DNA was isolated using phenol-chloroform extraction and ethanol precipitation. Logistic regression analysis was used in the statistical analysis to see the effect of genetic polymorphism to the various forms of CAs, while Poisson regression model was used to analyze the associations between the frequency of CAs. Results show a significant effect to CAs due to chemical exposure transported in the transit.
- Subjects
GENETIC toxicology; PHYSIOLOGICAL effects of chemicals; CHEMICAL transportation; CHROMOSOME abnormalities; RAILROAD trains; LYMPHOCYTES; RAILROAD employees; TRAIN attendants; GENETIC polymorphisms; BLOOD testing; LOGISTIC regression analysis; POISSON'S equation
- Publication
Environmental & Molecular Mutagenesis, 2009, Vol 50, Issue 4, p304
- ISSN
0893-6692
- Publication type
Article
- DOI
10.1002/em.20458