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- Title
A dialyzer-based flow system for validating dynamic contrast enhanced MR image acquisition.
- Authors
Rajan, Sunder; Herbertson, Luke; Bernardo, Marcelino; Choyke, Peter
- Abstract
Purpose Dynamic contrast enhanced magnetic resonance imaging (MRI) has proven to be quite sensitive for the characterization of masses and early response to therapy. However, it is fraught with a number of procedural challenges as well as a lack of standardization. In this article, we describe the use of a simple dialyzer-based flow system to evaluate reproducibility of dynamic contrast enhanced MRI under active flow conditions. Methods The MR signal during a bolus injection of Gd-DTPA was analyzed to test the precision and variability of contrast agent kinetics during a typical dynamic contrast enhanced MRI sequence. A simple model allows an estimation of the washout rate constant of Gd-DTPA through the polysulfone tubules of the dialyzer. Results The simple flow phantom described here provided reproducible measurements of the washout rate constants. The washout rate increased from 0.20 ± 0.005 min−1 to 0.25 ± 0.008 min−1 over 32 weeks. Measurements were also made at week 24 using dynamic computed tomography and found to be 0.27 ± 0.006 min−1. Overall, the computed tomography derived rate constants results were found be ∼12% higher than the corresponding MRI values. Conclusion In this study, we show that a simple dialyzer-based flow phantom can be used for testing dynamic contrast enhanced MRI pulse sequences and also allows for short-term reproducibility testing of rate constants. Magn Reson Med 72:41-48, 2014. © 2013 Wiley Periodicals, Inc.
- Publication
Magnetic Resonance in Medicine, 2014, Vol 72, Issue 1, p41
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.24887