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- Title
Total Synthesis of Lineaflavones A, C, D, and Analogues.
- Authors
Wang, Rui; Fu, Yu; Ma, Ran; Jin, Hongzhen; Zhao, Wei
- Abstract
The first total synthesis of lineaflavones A, C, D, and their analogues has been accomplished. The key synthetic steps include aldol/oxa-Michael/dehydration sequence reactions to assemble the tricyclic core, Claisen rearrangement and Schenck ene reaction to construct the key intermediate, and selective substitution or elimination of tertiary allylic alcohol to obtain natural compounds. In addition, we also explored five new routes to synthesize fifty-three natural product analogues, which can contribute to a systematic structure–activity relationship during biological evaluation.
- Subjects
CLAISEN rearrangement; ENE reactions; STRUCTURE-activity relationships; ALLYL alcohol; NATURAL products
- Publication
Molecules, 2023, Vol 28, Issue 5, p2373
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28052373