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- Title
Construction of 5-(Alkylamino)-6-aryl/alkylpyrazine-2,3-dicarbonitriles via the One-Pot Reaction of Alkyl Isocyanides with Aryl/Alkyl Carbonyl Chlorides and Diaminomaleonitrile: Fluorescence and Antimicrobial Activity Evaluation.
- Authors
Al-Azmi, Amal; John, Elizabeth
- Abstract
5-(Alkylamino)-6-aryl/alkylpyrazine-2,3-dicarbonitriles were successfully synthesized in good to moderate yields by reacting alkyl isocyanides with aryl/alkyl carbonyl chlorides, followed by the addition of diaminomaleonitrile. The synthesized pyrazines were fully characterized in this investigation, and X-ray crystal structure analysis was performed on some derivatives. The antibacterial and antifungal activities of the newly synthesized pyrazine-2,3-dicarbonitriles were assessed in addition to their UV and fluorescence results. All the compounds showed similar UV–Vis spectral features with absorption peaks (λmax) around 267, 303, and 373 nm.
- Subjects
PHOSGENE; ALKYL chlorides; ISOCYANIDES; FLUORESCENCE; ANTI-infective agents; PYRAZINES
- Publication
Molecules, 2022, Vol 27, Issue 23, p8278
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27238278