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- Title
Diabetic patients with and without sodium-glucose cotransporter-2 inhibitors use and cataract risk: real-world observational investigation.
- Authors
Hu, Wei-Syun; Lin, Cheng-Li
- Abstract
Purpose: We tried to define the association of type 2 diabetes mellitus (T2DM) patients with and without sodium-glucose cotransporter-2 inhibitors (SGLT2I) use and incident cataract using nationwide data in Taiwan. Methods: In a Cox proportional hazards regression model, we estimated the hazard ratios (HR) and 95% confidence intervals (95% CI). We considered risk factors for variables of sex, age, comorbidities and medications that we adjusted in multivariable Cox model. Results: We identified 20,768 T2DM patients in this study; 10,384 patients in the SGLT2I cohort, and 10,384 controls in the non-SGLT2I cohort. Compared with the T2DM patients without SGLT2I, T2DM patients using SGLT2I had a 2.04-fold increased risk of cataract, after adjustment by sex, age, comorbidities and medications. Conclusion: Increased risk of cataract among diabetic patients who took SGLT2I was found in this study.
- Subjects
TAIWAN; SODIUM-glucose cotransporters; PEOPLE with diabetes; TYPE 2 diabetes; CATARACT; GLYCOSYLATED hemoglobin; PROPORTIONAL hazards models
- Publication
Acta Diabetologica, 2023, Vol 60, Issue 7, p981
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-023-02087-y