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- Title
A Comparison of the Efficacy of Two Doses of Letrozole Alone or with Continuous Recombinant Follicle-Stimulating Hormone for Ovulation Induction in Anovulatory Women.
- Authors
Wang, Hai-Yan; Zheng, Peng-Sheng
- Abstract
Aims: To determine the efficacy of letrozole alone or with recombinant follicle-stimulating hormone (rFSH) for ovarian induction in anovulatory women. Methods: A total of 322 patients undergoing intrauterine insemination (IUI) were included in this retrospective study. Letrozole (2.5 or 5.0 mg) was administered from days 5 to 9 of menses, alone or followed with rFSH started on day 9 until the day of human chorionic gonadotropin administration. A single IUI was performed 24 h after ovulation. Results: The number of follicles, endometrial thickness and serum estradiol levels were significantly higher in the letrozole + rFSH groups than in the letrozole-alone groups (p < 0.05), but no significant difference was found between the two doses of letrozole, whether alone or with rFSH. Women treated with 5.0 mg/day of letrozole + rFSH required a total dose of rFSH similar to women treated with 2.5 mg/day of letrozole + rFSH (230.77 ± 118.29 vs. 258.55 ± 130.13 IU, respectively; p = 0.205). There was no significant difference in pregnancy rates between the two doses of letrozole, whether alone or with rFSH. Conclusion: Treatment with letrozole + rFSH was more efficacious than letrozole alone for pregnancy in the IUI program; however, the effect of 5.0 mg/day of letrozole versus 2.5 mg/day of letrozole on ovulation was equivalent, regardless of whether rFSH was used. © 2014 S. Karger AG, Basel
- Subjects
LETROZOLE; FOLLICLE-stimulating hormone; INDUCED ovulation; HUMAN artificial insemination research; PHARMACODYNAMICS; ESTRADIOL; DRUG dosage
- Publication
Gynecologic & Obstetric Investigation, 2015, Vol 79, Issue 4, p250
- ISSN
0378-7346
- Publication type
Article
- DOI
10.1159/000367847