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- Title
Efficacy of Magnesium Sulfate Treatment in Children with Acute Asthma.
- Authors
Özdemir, Ali; Doğruel, Dilek
- Abstract
<bold>Objective: </bold>Systemic administration of magnesium sulfate (MgSO4) has been proposed as a treatment for pediatric patients with acute asthma. However, previous trials show mixed results and uncertain evidence of benefit. The aim of the study was to ascertain whether intravenous (IV) MgSO4 improves lung function parameters in children with acute asthma.<bold>Methods: </bold>This was a prospective clinical trial. All patients with acute asthma received 40-50 mg/kg or maximum 1,500 mg (>30 kg) of single dose IV MgSO4, administered over 60 min. Spirometry was conducted before and 15 min after MgSO4 infusion.<bold>Results: </bold>One hundred and fifteen children aged 6 to 17 years presenting with acute asthma and FEV1 between 40% and 75% of predicted were included. Then, the patients were classified into 2 groups; mild asthma attack (FEV1 ranged from 60% to 75%; n = 50) or moderate asthma attack (FEV1 ranged from 40% to 59%; n = 65). The baseline characteristics were similar in both groups. The mean percent predicted pre and post values for FEV1/FVC ratio (mild group: 82.59 ± 9.46 vs. 85.06 ± 8.95; moderate group: 77.31 ± 11.17 vs. 79.99 ± 11.77), FEV1 (mild group: 67.14 ± 4.99 vs. 72.29 ± 8.05; moderate group: 48.50 ± 6.81 vs. 53.78 ± 9.81), PEF (mild group: 65.49 ± 12.32 vs. 71.37 ± 12.96; moderate group: 47.56 ± 11.78 vs. 51.97 ± 13.98), and FEF25-75 (mild group: 58.20 ± 12.24 vs. 66.57 ± 16.95; moderate group: 37.77 ± 11.37 vs. 43.41 ± 14.19) showed a statistically significant (p < 0.05 for all) bronchodilator effect after MgSO4 infusion in both groups with few side effects.<bold>Conclusion: </bold>Administration of IV MgSO4 was associated with improved pulmonary function in children with acute asthma.
- Subjects
MAGNESIUM sulfate; ASTHMA in children; ASTHMATICS; PEDIATRIC therapy; ASTHMA; DRUG therapy for asthma; INTRAVENOUS therapy; CLINICAL trials; CHILDREN'S hospitals; BRONCHODILATOR agents; SEVERITY of illness index; PULMONARY function tests; DOSE-effect relationship in pharmacology; LONGITUDINAL method; ACUTE diseases
- Publication
Medical Principles & Practice, 2020, Vol 29, Issue 3, p292
- ISSN
1011-7571
- Publication type
journal article
- DOI
10.1159/000506595