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- Title
The Role of Induced Sputum in Amiodarone-Associated Interstitial Lung Diseases.
- Authors
Fireman, Elizabeth; Topilsky, Ian; Viskin, Sami; Priel, Israel E.
- Abstract
Amiodarone, a highly effective medication for suppressing cardiac rhythm disturbances, may cause pulmonary injury, such as chronic interstitial lung diseases, in 5–15% of the patients who take it. We applied induced sputum (IS), a non-invasive technique, for diagnosing amiodarone-induced pulmonary toxicity. Four patients with interstitial lung disease who were treated by amiodarone for ischemic heart diseases were evaluated by a conventional clinical workup. All four patients showed marked interstitial pattern on computerized tomography and decreased diffusion capacity (DLCO-SB 51–76%). IS showed lymphocytosis, a high CD4 or CD8 count, eosinophilia and amiodarone in 3 of 4 patients. IS may be a useful tool for assessing amiodarone toxicity in patients with ischemic heart diseases and concomitant pulmonary side effects. Copyright © 2007 S. Karger AG, Basel
- Subjects
AMIODARONE; RESPIRATORY insufficiency; INTERSTITIAL lung diseases; PULMONARY toxicology; TOMOGRAPHY; MEDICAL radiography
- Publication
Cardiology, 2007, Vol 108, Issue 4, p223
- ISSN
0008-6312
- Publication type
Article
- DOI
10.1159/000096782