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- Title
The synthesis and antitubercular activity of 4,5-dihydro-1H-pyrazole derivatives with a basic epoxybenzo[7,8]oxocine framework.
- Authors
Stalinskaya, Alena L.; Dengis, Natalia A.; Vlasenko, Vasily S.; Kulakov, Ivan V.
- Abstract
The corresponding pyridyl chalcones were synthesized by the aldol-crotonic condensation of the acetyl derivative of epoxybenzo[7,8]-oxocino[4,3-b]pyridine with aromatic aldehydes. A subsequent cyclization with hydrazine hydrate in acetic acid led to the corresponding 4,5-dihydro-1H-pyrazole derivatives. An assessment of the resulting derivatives for antitubercular activity was carried out.
- Subjects
AROMATIC aldehydes; CHALCONES; ACETIC acid; HYDRAZINES; PYRIDINE; HYDRAZINE; HYDRAZINE derivatives
- Publication
Chemistry of Heterocyclic Compounds, 2024, Vol 60, Issue 1/2, p41
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-024-03291-6