We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Rational design, synthesis and binding mechanisms of novel benzyl geranate derivatives as potential eco‐friendly aphid repellents.
- Authors
Pan, Shi‐Xiang; Yang, Zhao‐Kai; Liu, Yan; Shi, Zhuo; Qin, Yao‐Guo; Qu, Cheng; Li, Xue‐Sheng; Zhou, Zheng‐Xin; Luo, Chen; Yang, Xin‐Ling
- Abstract
BACKGROUND: The push–pull strategy is considered as a promising eco‐friendly method for pest management. Plant volatile organic compounds (PVOCs) act as semiochemicals constitute the key factor in implementing this strategy. Benzyl alcohol and geraniol, as functional PVOCs, were reported to regulate insect behavior, showing the potential application in pest control. Using geraniol as lead, a geraniol derivative 5i with fine repellent activity was discovered in our previous work. In order to explore novel, eco‐friendly aphid control agents, a series of benzyl geranate derivatives was designed and synthesized using 5i as the lead and benzyl alcohol as the active fragment. RESULTS: Benzyl alcohol was firstly evaluated to have repellent activity to Acyrthosiphon pisum. Based on this repellent fragment, a series of novel benzyl geranate derivatives was rationally designed and synthesized using a scaffold‐hopping strategy. Among them, compound T9, with a binding affinity (Kd = 0.43 μm) and a substantial repellency of 64.7% against A. pisum, is the most promising compound. Molecule docking showed that hydrophobic and hydrogen‐bonding interactions substantially influenced the binding affinity of compounds with ApisOBP9. Additionally, T9 exhibited low‐toxicity to honeybees and ladybugs. CONCLUSION: Using a simple scaffold‐hopping strategy combined with active fragment benzyl alcohol, a new derivative T9, with high aphid‐repellency and low‐toxicity to nontarget organisms, can be considered as a novel potential eco‐friendly aphid control agent for sustainable agriculture. © 2023 Society of Chemical Industry.
- Subjects
SOCIETY of Chemical Industry (Great Britain); REPELLENTS; BENZYL alcohol; APHID control; VOLATILE organic compounds; PEA aphid; APHIDS
- Publication
Pest Management Science, 2024, Vol 80, Issue 3, p1099
- ISSN
1526-498X
- Publication type
Article
- DOI
10.1002/ps.7840