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- Title
Disease progression in proposed brain-first and body-first Parkinson's disease subtypes.
- Authors
Xu, Zhiheng; Hu, Tianyu; Xu, Chenqin; Liang, Xiaoniu; Li, Shiyu; Sun, Yimin; Liu, Fengtao; Wang, Jian; Tang, Yilin
- Abstract
A new Parkinson's disease (PD) subtyping model has been recently proposed based on the initial location of α-synuclein inclusions, which divides PD patients into the brain-first subtype and the body-first subtype. Premotor RBD has proven to be a predictive marker of the body-first subtype. We found compared to PD patients without possible RBD (PDpRBD–, representing the brain-first subtype), PD patients with possible premotor RBD (PDpRBD+, representing the body-first subtype) had lower Movement Disorders Society Unified Parkinson's Disease Rating Scale part III (MDS UPDRS-III) score (p = 0.022) at baseline but presented a faster progression rate (p = 0.009) in MDS UPDRS-III score longitudinally. The above finding indicates the body-first subtype exhibited a faster disease progression in motor impairments compared to the brain-first subtype and further validates the proposed subtyping model.
- Subjects
PARKINSON'S disease; DISEASE progression; ALPHA-synuclein
- Publication
NPJ Parkinson's Disease, 2024, Vol 10, Issue 1, p1
- ISSN
2373-8057
- Publication type
Article
- DOI
10.1038/s41531-024-00730-1