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- Title
Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses.
- Authors
Liu, Yalan; Li, Yuncheng; Hu, Qinxue
- Abstract
Although conventional vaccine approaches have proven to be successful in preventing infectious diseases in past decades, for vaccine development against emerging/re-emerging viruses, one of the main challenges is rapid response in terms of design and manufacture. mRNA vaccines can be designed and produced within days, representing a powerful approach for developing vaccines. Furthermore, mRNA vaccines can be scaled up and may not have the risk of integration. mRNA vaccines are roughly divided into non-replicating mRNA vaccines and self-amplifying RNA (saRNA) vaccines. In this review, we provide an overview of saRNA vaccines, and discuss future directions and challenges in advancing this promising vaccine platform to combat emerging/re-emerging viruses.
- Subjects
VACCINES; VACCINE manufacturing; VACCINE development; COMMUNICABLE diseases
- Publication
Vaccines, 2023, Vol 11, Issue 7, p1142
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines11071142