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- Title
Effect of omega-3 fatty acids on cardiovascular risk factors in patients with type 2 diabetes mellitus and hypertriglyceridemia: an open study.
- Authors
DE LUIS, D. A.; CONDE, R.; ALLER, R.; IZAOLA, O.; SAGRADO, M. GONZÁLEZ; CASTRILLÓN, J. L. PEREZ; DUEÑAS, A.; ROMERO, E.
- Abstract
Background and Objectives: Epidemiological and interventional studies suggest that a high dietary intake of n-3 polyunsaturated fatty acids may confer a protective effect against atherosclerotic disease and reduce serum triglycerides levels. The aim of our study was to investigate the effectivity on triglyceride levels and inflammatory markers of a concentrated of n-3 fatty acids in patients with type 2 diabetes mellitus and hypertriglyceridaemia. Subjects: A total of 30 patients (16 males and 14 females) with diabetes mellitus type 2 and hypertriglyceridemia (>200 mg/dl) were included in the study. Patients received two capsules of eicosapentaenoic 465 mg and docosahexanoic 375 mg daily for 12 weeks. Results: Triglycerides levels and non HDL-cholesterol decreased (326±113.5 vs. 216.4±57 mg/dl; p<0.05) and (103.87±44 vs. 89.6±14 mg/dl; p<0.05), respectively. HDL-cholesterol levels increased (39.6±10.7 vs. 46.4±8.7 mg/dl; p<0.05). C reactive protein decreased (5.98±3.9 vs. 3.9±1.6 mg/dl; p<0.05) and TNF-alpha levels decreased (16.24±5.5 vs. 13.3±5.8 pg/dl; p<0.05), without significant changes in IL-6 levels. In conclusion, an n-3 polyunsaturated intervention improved lipid profile and inflammatory markers in patients with diabetes mellitus type 2 and hypertriglyceridaemia.
- Subjects
OMEGA-3 fatty acids; CARDIOVASCULAR diseases; TYPE 2 diabetes; HYPERTRIGLYCERIDEMIA; EICOSAPENTAENOIC acid; DOCOSAHEXAENOIC acid
- Publication
European Review for Medical & Pharmacological Sciences, 2009, Vol 13, Issue 1, p51
- ISSN
1128-3602
- Publication type
Article