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- Title
Effective aerosol delivery during high-frequency ventilation in neonatal pigs.
- Authors
SOOD, Beena G.; SHEN, Yimin; LATIF, Zahid; GALLI, Bob; DAWE, Elizabeth J.; HAACKE, E. Mark
- Abstract
Background and objective: Pulmonary delivery of aerosols during high-frequency oscillatory ventilation (HFOV) has not been studied in vivo. This study investigated the pulmonary delivery of aerosolized gadopentetate dimeglumine (Gd-DTPA) in a HFOV circuit in piglets using MRI to visualize contrast excretion in the kidneys. Methods: Four ventilated piglets (3–7 days old, 1.7–2.4 kg at birth) received aerosolized Gd-DTPA in a HFOV circuit for different durations of time (60, 30, 20 and 10 min). Aerosols were generated using the MiniHeart jet nebulizer. As MR-compatible HFOV was not available, aerosolized Gd-DTPA was administered in the HFOV circuit outside the MR suite followed by MRI 10–20 min later. T1-weighted spin echo sequences were obtained using the Bruker/Siemens 4T MR scanner. Results: Enhancement of the kidneys was observed 10 min after aerosol initiation in piglets who received Gd-DTPA aerosol for 60, 30 and 20 min in the HFOV circuit but not in the piglet who received aerosol for 10 min. Renal concentration of Gd-DTPA, determined from the signal intensity, increased linearly with time until 40 min post Gd-DTPA delivery. Conclusions: Effective pulmonary aerosol delivery during HFOV was confirmed by contrast visualization in the kidneys within 30 min of aerosol initiation reflecting, alveolar absorption, glomerular filtration and renal concentration.
- Subjects
AEROSOLS; PIGLETS; MAGNETIC resonance imaging; KIDNEYS; GLOMERULAR filtration rate
- Publication
Respirology, 2010, Vol 15, Issue 3, p551
- ISSN
1323-7799
- Publication type
Article
- DOI
10.1111/j.1440-1843.2010.01714.x