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- Title
Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells.
- Authors
Kim, Sang Hoon; Song, Jae Ho; Kim, Min Ji; Song, Mun Gu; Ku, Angel A.; Bandyopadhyay, Sourav; McCormick, Frank; Kim, Sung Eun
- Abstract
Cancer cells utilize multiple nutrient scavenging mechanisms to support growth and survival in nutrient-poor, hypoxic tumor microenvironments. Among these mechanisms, macropinocytosis has emerged as an important pathway of extracellular nutrient acquisition in cancer cells, particularly in tumors with activated RAS signaling, such as pancreatic cancer. However, the absence of a clinically available inhibitor, as well as the gap of knowledge in macropinocytosis regulation, remain a hurdle for its use for cancer therapy. Here, we use the Informer set library to identify novel regulators of macropinocytosis-dependent growth in pancreatic cancer cells. Understanding how these regulators function will allow us to provide novel opportunities for therapeutic intervention.
- Subjects
PANCREATIC cancer; GROWTH regulators; EARLY detection of cancer; INFORMERS; PINOCYTOSIS
- Publication
Metabolites (2218-1989), 2022, Vol 12, Issue 9, p831
- ISSN
2218-1989
- Publication type
Article
- DOI
10.3390/metabo12090831