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- Title
Zinc Oxide Tetrapods Modulate Wound Healing and Cytokine Release In Vitro—A New Antiproliferative Substance in Glaucoma Filtering Surgery.
- Authors
Sonntag, Svenja Rebecca; Gniesmer, Stefanie; Gapeeva, Anna; Adelung, Rainer; Cojocaru, Ala; Mishra, Yogendra Kumar; Kaps, Sören; Tura, Aysegül; Grisanti, Swaantje; Grisanti, Salvatore; Nassar, Khaled
- Abstract
Thus, a brief exposure of the scleral flap and conjunctiva to ZnO-T during glaucoma surgery may be a suitable option to deliver high concentrations of ZnO-T. Extended-release systems or coated implants may be suitable to use for lower concentrations of tetrapods to suppress wound healing. In detail, our experiments showed that fibroblasts tolerated treatment with concentrations of ZnO-T as high as 10 µg/mL for 6 h without toxic effects, while long-term exposure of the cells led to a significant decrease in cell count, even at the low concentration of 5 µg/mL. Zinc Oxide Tetrapods Modulate Wound Healing and Cytokine Release In Vitro - A New Antiproliferative Substance in Glaucoma Filtering Surgery Keywords: glaucoma filtering surgery 1; nanotechnology 2; ZnO tetrapods 3; postoperative encapsulation 3; antiproliferative substances 4 EN glaucoma filtering surgery 1 nanotechnology 2 ZnO tetrapods 3 postoperative encapsulation 3 antiproliferative substances 4 1691 18 11/17/22 20221101 NES 221101 1.
- Subjects
MYOFIBROBLASTS; WOUND healing; FILTERING surgery; HYPERTROPHIC scars; ZINC oxide; TETRAPODS; HEPATOCYTE growth factor; CYTOKINES
- Publication
Life (2075-1729), 2022, Vol 12, Issue 11, p1691
- ISSN
2075-1729
- Publication type
Article
- DOI
10.3390/life12111691