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- Title
Cuminaldehyde Effects in a MIA-Induced Experimental Model Osteoarthritis in Rat Knees.
- Authors
Morais, Sebastião Vieira de; Mendonça, Priscylla Gouveia; Vasconcelos, Cleydlenne Costa; Lopes, Paloma Larissa Arruda; Garcia, João Batista Santos; Calzerra, Natalia Tabosa Machado; Queiroz, Thyago Moreira de; Lima, Silvia Tereza de Jesus Rodrigues Moreira; Silva, Gyl Eanes Barros; Lopes, Alberto Jorge Oliveira; Cartágenes, Maria do Socorro de Sousa; Domingues, Gerson Ricardo de Souza
- Abstract
Osteoarthritis (OA) is a chronic degenerative disease that has a significant global impact. It is associated with aging and characterized by widespread joint destruction. Cuminaldehyde is a biologically active component of essential oils that has shown promise in the treatment of nociceptive and inflammatory diseases. This study investigated the effects of cuminaldehyde on an experimental model of osteoarthritis induced in rat knees. Cuminaldehyde was found to be as effective as indomethacin in reducing pain in all evaluated tests, including forced walking, functional disability of weight distribution on the legs, and spontaneous pain in animals with osteoarthritis. The knees of animals treated with cuminaldehyde had significantly higher radiographic and histopathological scores than those of animals that did not receive the treatment. Cuminaldehyde also modulated the production of pro-inflammatory cytokines. In vitro assays showed that cuminaldehyde preferentially inhibits COX-2 enzyme activity. In silico studies demonstrated that cuminaldehyde has satisfactory energy affinity parameters with opioid receptors and COX-2. These findings suggest that cuminaldehyde's anti-inflammatory activity is multifactorial, acting through multiple pathways. Its nociceptive activity occurs via central and peripheral mechanisms. Cuminaldehyde modulates the immune response of the inflammatory process and may be considered a leading compound for the development of new anti-inflammatory and analgesic drugs.
- Subjects
KNEE osteoarthritis; KNEE; INFLAMMATION; ANTI-inflammatory agents; DEGENERATION (Pathology); ESSENTIAL oils; OPIOID receptors
- Publication
Metabolites (2218-1989), 2023, Vol 13, Issue 3, p397
- ISSN
2218-1989
- Publication type
Article
- DOI
10.3390/metabo13030397