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- Title
Simple one-pot green method for large-scale production of mesalamine, an anti-inflammatory agent.
- Authors
Vijaya Lakshmi, C.; Katari, Naresh Kumar; Jonnalagadda, Sreekantha B.
- Abstract
We report a rapid and efficient synthesis protocol for mesalamine via a green approach with 2-chloro-5-nitrobenzoic acid as the starting material, for its large-scale production. This one-pot method involves the conversion of a chloro group into a hydroxyl group using aqueous KOH solution, followed by the reduction of a nitro group to amine using Pd/C. The product was characterised and confirmed by 1H-nuclear magnetic resonance (NMR), 13C NMR, IR and mass spectrometry techniques. The salient features of the method include excellent conversion (99.3%), high yield (93%), cost effectiveness and validated results for benign, large-scale production.
- Subjects
MESALAMINE; ANTI-inflammatory agents; NITROBENZOIC acid; HYDROXYL group; NUCLEAR magnetic resonance
- Publication
Green Processing & Synthesis, 2019, Vol 8, Issue 1, p320
- ISSN
2191-9542
- Publication type
Article
- DOI
10.1515/gps-2018-0108