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- Title
Transcriptional coregulators of the nuclear receptor superfamily: coactivators and corepressors.
- Authors
Lee, J. W.; Lee, Y. C.; Na, S.-Y.; Jung, D.-Ju; Lee, S.-K.
- Abstract
Nuclear receptors, many of which undergo a major conformational change upon binding specific ligand, belong to a superfamily of proteins that bind to specific DNA sequences and control gene transcription. They regulate the assembly of a transcriptional preinitiation complex at the promoter of target genes and modulate their expression in response to ligand. In particular, nuclear receptors repress or stimulate transcription by recruiting corepressor or coactivator proteins, in addition to directly contacting the basal transcription machinery. In this review, we discuss recent progress in studies of these transcriptional coregulators of nuclear receptors.
- Subjects
TRANSCRIPTION factors; PROTEINS; NUCLEAR receptors (Biochemistry); CELL receptors; GENETIC repressors; PLASMINOGEN activators
- Publication
Cellular & Molecular Life Sciences, 2001, Vol 58, Issue 2, p289
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/PL00000856