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- Title
Assessment of Immunological Effects of Low-Level Er: YAG Laser Radiation.
- Authors
Ansari, Mojtaba; Rezaei-Tavirani, Mostafa; Hamzeloo-Moghadam, Maryam; Vafaee, Reza; Razzaghi, Mohhamadreza; Nikzamir, Mahfam; Nejad, Mohammad Rostami; Azodi, Mona Zamanizn
- Abstract
Introduction: Low-level laser radiation has a significant effect on cell proliferation. Various investigations into the effect of Er: YAG laser on the treated cell lines have been published. Determining core targeted proteins is an attractive subject. This research aimed at identifying the critical targeted protein by a low-level Er: YAG laser in primary osteoblast-like cells. Methods: Data were extracted from the literature about proteomic assessment of 3.3 J/cm2 of lowlevel Er: YAG laser radiation on osteoblast-like cells of rat calvaria. The significant differentially expressed proteins plus 100 first neighbors were analyzed via network analysis and gene ontology enrichment. Results: Nine differentially expressed proteins among the 12 queried proteins were included in the main connected component. Analysis revealed that Cxcl1 was a key targeted protein in response to laser radiation. The presence of Cxcl1 in the significant cellular pathways indicated that cell growth and proliferation were affected. Conclusion: It can be concluded that the immune system is affected by the laser to activate cellular defense against stress.
- Subjects
LASER therapy; YAG lasers; LASER beams; GENE expression; CELL growth; CELL proliferation
- Publication
Journal of Lasers in Medical Sciences, 2022, Vol 13, p1
- ISSN
2008-9783
- Publication type
Article
- DOI
10.34172/jlms.2022.25