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- Title
Editorial: Cell-Cell and Cell-Matrix Adhesion in Immunobiology and Cancer.
- Authors
Murai, Toshiyuki; Kawashima, Hiroto; Naor, David
- Abstract
These interactions are mediated at the cell surface by adhesion molecules including integrins, selectins, CD44, and lectin molecules such as sialic acid-binding immunoglobulin-like lectins (Siglecs) as well as cell-cell interaction molecules such as cadherins. Cancer immunotherapy has shown great progress in the past decade, particularly focusing on immune modulation by immune checkpoint blockade (ICB), which has revolutionized cancer treatment and has fundamentally changed the outcome for certain groups of patients with advanced cancer. Bidirectional communication between cancer cells and their tumor microenvironment (TME) is critical for cancer progression, and thus cancer cell-ECM interaction in TME may be a new target for immunotherapy ([5]).
- Subjects
CELL-matrix adhesions; IMMUNOLOGY; PROTEOGLYCANS; CELL adhesion molecules; SERUM response factor
- Publication
Frontiers in Immunology, 2020, p1
- ISSN
1664-3224
- Publication type
Editorial
- DOI
10.3389/fimmu.2019.03126