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- Title
Activation of lymphocytes after platelet allotransfusion possessing only class I MHC product.
- Authors
Pócsik, É; Mihalik, R.; Gyódi, É; Réti, M.; Pál&oaute;czi, K.; Petrányi, G. G.; Benczur, M.
- Abstract
After platelet allotransfusion, we found a characteristic increase in the expression of interleukin-2 receptor, dipeptydilpeptidase IV (CD26). activation-inducer molecule (AIM, CD69) and transferrin receptors (CD71) on day 3 indicating that important functional molecules expressed on the activation of lymphocytes by allogeneic platelets. At the same time, no consistent increase of other activation molecules such as Ki-1 (CD30), intercellular adhesion molecule (ICAM-1, CD54) and Ki-24 (CDw70) antigen expression was detected, probably as a result of the selective activation of some lymphocyte subsets. In order to obtain further evidence for the in vivo activation triggered by allogeneic platelets, a subsequent step of T cell activation towards differentiation was investigated with monoclonal antibodies lo leucocyte common antigens. A sharp expression of the UCHL1, coupled with a decrease of the CD45R molecule was detected on day 7 or 14, suggesting a T cell priming.
- Subjects
BLOOD transfusion; BLOOD platelets; INTERLEUKIN-2; LYMPHOCYTES; IMMUNOGLOBULINS; T cells
- Publication
Clinical & Experimental Immunology, 1990, Vol 82, Issue 1, p100
- ISSN
0009-9104
- Publication type
Article