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- Title
Serum interleukin--2--receptor in coeliac disease: response to treatment and gluten challenge.
- Authors
Crabtree, J. E.; Heatley, R. V.; Juby, L. D.; Howdle, P. D.; Losowsky, M. S.
- Abstract
Concentrations of the soluble interleukin-2 receptor (sIL-2R) in the serum of 33 patients with coeliac disease were measured by ELISA. The levels of sIL-2R were significantly raised in 15 patients with untreated coeliac disease compared with treated patients and age- and sex-matched symptomatic and non-symptomatic control groups. Longitudinal studies in individual coeliac patients showed that serum sIL-2R fell following commencement of a gluten-free diet. Gluten challenge of 16 treated coeliac patients for I week resulted in a significant increase in serum sIL-2R, which returned lo pre-challenge levels within 4 weeks of recommencement of a gluten-free diet. We suggest that serum sIL- 2R levels in patients with coeliac disease reflect specific immunological activation in response to gluten ingestion. Measurement of serum sIL-2R may therefore be useful in the assessment of response to treatment in patients with coeliae disease.
- Subjects
CELIAC disease; BLOOD plasma; PLANT proteins; DIGESTIVE system diseases; MALABSORPTION syndromes; DIET therapy
- Publication
Clinical & Experimental Immunology, 1989, Vol 77, Issue 3, p345
- ISSN
0009-9104
- Publication type
Article