We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The mitogenic effect of the lymphocytosis promoting factor from Bordetella pertussis on human T<sub>γ</sub> and non-T<sub>γ</sub> cells.
- Authors
Kashiwa, H.; Hyodo, S.; Kishi, T.; Karakawa, T.; Kittaka, E.; Suzawa, T.; Sakano, T.; Usui, T.
- Abstract
We studied the effect of lymphocytosis promoting factor (LPF). derived from the supernatant fluid of a culture of phase I Bordetella pertussis strain Tohama. on human lymphocyte proliferation. LPF was a potent mitogen for human mononuclear cells. specifically T cells. LPF failed to induce cytoplasmic immunoglobulin production by B cells. Removal of the monocytes from the T cell fraction diminished responses to LPF. but the response could be restored completely by the addition of 50",, monocytes. These results suggest that LPF-induced cell proliferation is at least partially dependent on monocytes. In contrast to PHA, LPF stimulated T&lamda; cells to a greater extent than non-T&lamda; cells., but the magnitude of the T&lamda; or non-T&lamda; cell response was less than that of T cells, indicating that synergistic interactions between T&lamda; and non-T&lamda; cells are required for maximal response.
- Subjects
LYMPHOCYTES; BORDETELLA; MITOGENS; LEUCOCYTES; BRUCELLACEAE; LECTINS
- Publication
Clinical & Experimental Immunology, 1984, Vol 58, Issue 2, p436
- ISSN
0009-9104
- Publication type
Article