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- Title
Failure to induce delayed-type hypersensitivity to Mycobacterium leprae in long-term treated lepromatous leprosy patients.
- Authors
Smelt, A. H. M.; Rees, R. J. W.; Liew, F. Y.
- Abstract
Lepromatous leprosy (LL) patients whose bacillary load has decreased to almost undetectable levels by long-term chemotherapy failed to develop delayed-type hypersensitivity (DTH) to Mycobacterium leprae antigen following immunization with killed armadillo-derived M. leprae. When these LL patients were immunized with killed M. leprae in a mixture with live BCG, only DTH to purified protein derivative (PPD) was induced. These results are further evidence that immunolngical unresponsiveness to the leprosy antigen of patients with lepromatous leprosy is antigen-specific and non-reversible.
- Subjects
MYCOBACTERIUM leprae; MYCOBACTERIAL diseases; HANSEN'S disease; BCG vaccines; DRUG therapy; IMMUNIZATION
- Publication
Clinical & Experimental Immunology, 1981, Vol 44, Issue 3, p507
- ISSN
0009-9104
- Publication type
Article