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- Title
Cardiovascular safety of antihistamines.
- Authors
Olasińska-Wiśniewska, Anna; Olasiński, Jerzy; Grajek, Stefan
- Abstract
Histamine is a mediator, which increases the permeability of capillaries during the early phase of allergic reaction, causes smooth muscle contraction of bronchi and stimulates mucous glands in the nasal cavity. Antihistamines are the basis of symptomatic treatment in the majority of allergic diseases, especially allergic rhinitis, allergic conjunctivitis, urticaria and anaphylaxis. The cardiotoxic effects of the two withdrawn drugs, terfenadine and astemizole, were manifested by prolonged QT intervals and triggering torsades de pointes (TdP) caused by blockade of the 'rapid' IKr potassium channels. These phenomena, however, are not a class effect. This review deals with a new generation of antihistamine drugs in the context of QT interval prolongation risk.
- Subjects
CARDIOVASCULAR system physiology; ANTIHISTAMINES; TREATMENT effectiveness; ALLERGIES; SMOOTH muscle contraction; ASTEMIZOLE
- Publication
Advances in Dermatology & Allergology / Postępy Dermatologii i Alergologii, 2014, Vol 31, Issue 3, p182
- ISSN
1642-395X
- Publication type
Article
- DOI
10.5114/pdia.2014.43191