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- Title
Therapeutic factors considered according to the preoperative splenic volume for a prolonged increase in platelet count after partial splenic embolization for liver cirrhosis.
- Authors
Hayashi, Hiromitsu; Beppu, Toru; Okabe, Kazutoshi; Masuda, Toshiro; Okabe, Hirohisa; Ishiko, Takatoshi; Baba, Hideo
- Abstract
Infarcted splenic volume has been identified as the predictive factor for a prolonged increase in platelet count after partial splenic embolization (PSE). However, despite enough infarcted splenic volume, some patients show only a slight increase in platelet counts after PSE because of rapid regrowth of the noninfarcted splenic parenchyma within several months post-PSE. The purpose of this study was to determine the therapeutic factors based on the preoperative splenic volume for a prolonged increase in platelet counts after PSE. In 72 cirrhotic patients with follow-ups longer than 1 year post-PSE, depending on the preoperative splenic volume, the splenic factors associated with a prolonged increase in platelet counts at 1 year after PSE were retrospectively examined. In 57 patients with preoperative splenic volumes ≤700 ml, the preoperative splenic volume ( P = 0.001), infarcted splenic volume ( P < 0.001), and splenic infarction ratio ( P = 0.001) showed positive correlations with increments in platelet counts at 1 year post-PSE. In 15 patients with preoperative splenic volumes >700 ml, noninfarcted splenic volume ( P = 0.003) and splenic infarction ratio ( P = 0.002) showed negative and positive correlations with the increment in platelet counts at 1 year post-PSE, respectively. In patients with splenic volumes ≤700 ml, the infarcted splenic area significantly affects the prolonged increase in platelet counts post-PSE. In patients with splenic volumes >700 ml, the noninfarcted splenic area is significant.
- Subjects
THERAPEUTIC embolization; NECROSIS; LIVER diseases; BLOOD platelets; BLOOD cells
- Publication
Journal of Gastroenterology, 2010, Vol 45, Issue 5, p554
- ISSN
0944-1174
- Publication type
Article
- DOI
10.1007/s00535-009-0185-9