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- Title
A Prospective, Randomized Study of High Cut Off Hemofiltration in Septic Patients with Acute Renal Failure.
- Authors
Morgera, S.; Haase, M.; Kuß, T.; Neumayer, H. -H.
- Abstract
Objective: High cut-off hemofilters are characterized by an increased effective pore size designed to facilitate the elimination of inflammatory mediators in sepsis. This study analyzes the impact of a newly developed high cut-off hemofilter on clinical parameters and on cytokine clearance rates. Methods: Thirty patients with sepsis-induced acute renal failure were prospectively randomized to receive either high cut off (P2SH, Gambro Medical Research, Hechingen, Germany; in vitro cut off: 100 kD) or conventional hemofiltration (PF11, Gambro, Hechingen, Germany; in vitro cut off 30 KD). The hemofiltration study period was restricted to 5 days. Primary endpoints were the need for vasopressive support and the course of the plasma levels of IL-6 and IL-1ra. Results: Both groups did not differ in respect to main clinical parameters prior to hemofiltration. 28 day mortality was 30% in the overall group. The need for vasopressive support declined in both groups with a slight advantage in favor for the high cut off hemofiltration group. IL-6 and IL-1ra cytokine clearance rates were significantly higher in the high cut off hemofiltration group (p < 0.001). Conclusions: High cut off hemofiltration is an emerging new hemofiltration modality for septic patients with acute renal failure. High cut off hemofiltration is well tolerated hemodynamically and achieves high clearance rates for IL-6 and IL-1ra
- Subjects
INFLAMMATORY mediators; KIDNEY diseases; INTERLEUKIN-6; INTERLEUKIN-1; ACUTE kidney failure
- Publication
Kidney & Blood Pressure Research, 2004, Vol 27, Issue 5/6, p304
- ISSN
1420-4096
- Publication type
Article