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- Title
بررسی اثر تعاملی مصرف وارفارین با تمرینا ت تداومی و تناوبی بر مقادیر پروتئین MGP قلبی و شاخصهاي عملکرد کلیوي در موشهاي صحرایی مدل انفارکتوس قلبی: یک مطالعه تجربی
- Authors
Abbasi, Tooran; Banaeifar, Abdolali; Arshadi, Sajad; Kazemzadeh, Yaser
- Abstract
Background and Objectives: Heart-kidney disorders affect on each other. Exercise training can control heart and kidney cell damages. The aim of this study is to determine the effect of exercise training and warfarin administration on cardiac matrix Gla protein (MGP) and indices of renal injury in rats of myocardial infarction model. Materials and Methods: In this experimental study, 42 male Sprague-Dawley rats (180-220 grams) were randomly divided into 7 groups of healthy control, myocardial infarction or ischemia (ISC), ISC+interval training, ISC+ continuous training, ISC+warfarin, ISC+interval training+warfarin, and ISC+continuous training+warfarin. The duration of interval and continuous training was eight weeks, five sessions per week. Induction of myocardial infarction was performed with subcutaneous injection of isoproterenol. Cardiac MGP was measured by western blotting, creatinine and blood urea nitrogen (BUN) by photometric method, and cystatin C by Turbidimetry. Glomerular filtration rate (GFR) was calculated according to cystatin C consideration. Independent t-test and twofactor analysis of variance were used to analyze the data. Results: Myocardial infraction decreased MGP protein (p=0.001), increased creatinine (p=0.001), BUN (p=0.002), and cystatin C (p=0.001), and decreased GFR (p=0.001) compared to the control group. The main effect of exercise type on all variables, the main effect of warfarin on MGP and BUN, and also interaction of warfarin and exercise type on MGP were significant. Conclusion: Exercise training had a better effect on cardiac MGP and control of renal injury markers compared to warfarin. Therefore, in heart and kidney diseases with warfarin therapy, exercise training should be carefully planned.
- Subjects
WARFARIN; KIDNEYS
- Publication
Journal of Rafsanjan University of Medical Sciences, 2022, Vol 21, Issue 2, p165
- ISSN
1735-3165
- Publication type
Article