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- Title
Preparation and Biological Activities of Some Heterocyclic Compounds Derivatives from 2-Aminothiazoles.
- Authors
Alrammahi, Faez Abdul-hussein
- Abstract
In the current investigation, two series of 2-amino thiazole derivatives were prepared. The first series involved synthesis of (Z)-3-(thiazol-2-ylimino)indolin-2-one (A1) as Schiff base derivatives of 2-amino thiazole and isatin, then synthesis of compounds A5, A6 and A7 as five membered rings (imidazolidins) by using different amino acids, and synthesis of compounds A3 and A4 as seven membered rings (1,3-oxazepine-di-one) by using maleic and phthalic anhydrides respectively. In the second series, 2-amino thiazole was treated with acetyl acetone to form (2E,4E)-N2,N4-di(thiazol-2-yl) pentane-2,4-diimine (A2) as di-Schiff base derivatives, and finally the preparation of imidazolidin (A8) by using 2 mol of tyrosine and preparation of tetrazole derivative (A9) by using 2 mol of sodium azide. The biological study for the above two series indicated that both gram-negative and grampositive activities were noticed.
- Subjects
THIAZOLE derivatives; HETEROCYCLIC compounds; GRAM-positive bacteria; AMINO acid synthesis; IMIDAZOLIDINES; SCHIFF bases
- Publication
Nano Biomedicine & Engineering, 2018, Vol 10, Issue 2, p129
- ISSN
2150-5578
- Publication type
Article
- DOI
10.5101/nbe.v10i2.p129-140